Idiosyncratic Adverse Drug Reactions: Current Concepts
نویسندگان
چکیده
منابع مشابه
Idiosyncratic adverse drug reactions: current concepts.
Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow. Clinical characteristics suggest that IDRs are immune mediated, and there is substantive evidence that most, but not all, IDRs are caused by chemically reactive species. However, rigorou...
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Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients, and develop mostly unpredictably in susceptible individuals only. These reactions are generally thought to account for up to 10% of all adverse drug reactions, but their frequency may be higher depending on t...
متن کاملIdiosyncratic drug reactions: past, present, and future.
Although the major working hypothesis for the mechanism of idiosyncratic drug reactions (IDRs), the hapten hypothesis, has not changed since 1987, several hypotheses have been added, for example, the danger hypothesis and the pharmaceutical interaction hypothesis. Genetic studies have found that several IDRs are linked to specific HLA genes, providing additional evidence that they are immune-me...
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INTRODUCTION Surgical patients are exposed to multiple foreign substances in the perioperative period including drugs, blood products, or environmental antigens such as latex. Because any substance can produce an allergic or adverse reaction, clinicians must be ready to manage patients in this perioperative environment. The most life-threatening form of an allergic reaction is anaphylaxis, howe...
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ژورنال
عنوان ژورنال: Pharmacological Reviews
سال: 2013
ISSN: 0031-6997,1521-0081
DOI: 10.1124/pr.113.007450